| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian women
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| Autores: |
Araújo,Karine Lourenzone
Rezende,Lucas Cunha Dias de
Souza,Letícia Soncini
Daltoé,Renata Dalmaschio
Madeira,Klesia Pirola
Paes,Marcela Ferreira
Herkenhoff,Fernando Luiz
Rangel,Letícia Batista Azevedo
Silva,Ian Victor
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| Data: |
2011-12-01
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| Ano: |
2011
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| Palavras-chave: |
Polymorphism
Estrogen Receptor
Brazilian Women
Prevalence
Linkage disequilibrium
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| Resumo: |
The aim of this work was to study the estrogen receptor alpha (ERS1) PvuII and XbaI gene polymorphisms prevalence in randomly selected women population from Rio de Janeiro and Espírito Santo states in Brazil by polymerase chain reaction restriction fragment lengths polymorphism (PCR_RFLP) methodology. It was shown that Rio de Janeiro women exhibited a significantly different prevalence of XbaI polymorphism comparing to Espirito Santo women. Nonetheless, similar prevalence of PvuII polymorphism was found in both women´s populations. Moreover, a strong linkage disequilibrium was observed between these SNPs reinforcing the hypothesis of differential pattern of inheritance observed on such populations.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600010
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132011000600010
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.54 n.6 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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